I love DF1! DF2:JK is the best one in the franchise though, like one of my all time favorite games.
But yeah, that Xpadder program is pretty cool, it lets you map out a bunch of different profiles for different games and then it's just as simple as swapping out controller configurations and firing up your game of choice! I've been playing Oblivion and Indiana Jones & The Emperor's Tomb with it thus far with great results, and neither of those games was originally set up to be played with a controller.